Table 2.
Correlations between gene mutation types and clinicpathological characteristics.
|
KRAS and PIK3CA wild-type |
KRAS mutations alone |
PIK3CA mutations alone |
KRAS and PIK3CA bi-mutations |
P value |
P value |
P value |
P value |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | N | % | (bi-mutations vs wild-type) | (bi-mutations vs KRAS mutations alone) | (bi-mutations vs PIK3CA mutations alone) | ||
| Sex | ||||||||||||
| Female | 113 | 35.20 | 112 | 44.80 | 17 | 58.60 | 23 | 41.80 | 0.022⁎ | 0.345 | 0.687 | 0.143 |
| Male | 208 | 64.80 | 138 | 55.20 | 12 | 41.40 | 32 | 58.20 | ||||
| Age, years | ||||||||||||
| <60 years | 175 | 54.50 | 109 | 43.60 | 14 | 48.30 | 23 | 41.80 | 0.047⁎ | 0.081 | 0.809 | 0.571 |
| ≥60 years | 146 | 45.50 | 141 | 56.40 | 15 | 51.70 | 32 | 58.20 | ||||
| CEA level | ||||||||||||
| 0–5 ng/ml | 197 | 62.30 | 128 | 53.10 | 18 | 62.10 | 33 | 60.00 | 0.171 | 0.741 | 0.355 | 0.854 |
| >5 ng/ml | 119 | 37.70 | 113 | 46.90 | 11 | 37.90 | 22 | 40.00 | ||||
| CA-199 level | ||||||||||||
| 0–37 ng/ml | 285 | 89.90 | 192 | 79 | 25 | 86.20 | 41 | 74.50 | 0.001⁎ | 0.001⁎ | 0.469 | 0.216 |
| > 37 ng/ml | 32 | 10.10 | 51 | 21.00 | 4 | 13.80 | 14 | 25.50 | ||||
| CA-125 level | ||||||||||||
| 0–35 ng/ml | 296 | 93.70 | 220 | 90.50 | 22 | 75.90 | 47 | 85.50 | 0.005⁎ | 0.033⁎ | 0.265 | 0.275 |
| >35 ng/ml | 20 | 6.30 | 23 | 9.50 | 7 | 24.10 | 8 | 14.50 | ||||
| HER2 | ||||||||||||
| Positive | 122 | 39.00 | 91 | 37.00 | 7 | 24.10 | 14 | 26.40 | 0.165 | 0.08 | 0.143 | 0.821 |
| Negative | 191 | 61.00 | 155 | 63.00 | 22 | 75.90 | 39 | 73.60 | ||||
| KI67 | ||||||||||||
| Positive | 99 | 31.30 | 60 | 24.40 | 5 | 17.20 | 10 | 18.50 | 0.065 | 0.056 | 0.356 | 0.885 |
| Negative | 217 | 68.70 | 186 | 75.60 | 24 | 82.80 | 44 | 81.50 | ||||
| Tumor location | ||||||||||||
| Proximal colon | 43 | 13.60 | 52 | 21.50 | 10 | 34.50 | 24 | 44.40 | <0.001⁎ | <0.001⁎ | 0.002⁎ | 0.013⁎ |
| Distal colon | 117 | 37.00 | 60 | 24.80 | 14 | 48.30 | 10 | 18.50 | ||||
| Rectum | 156 | 49.40 | 130 | 53.70 | 5 | 17.20 | 20 | 37.00 | ||||
| MSI status | ||||||||||||
| MSI-L/MSI-H | 20 | 6.30 | 13 | 5.20 | 6 | 20.70 | 3 | 5.50 | 0.015⁎ | 0.812 | 0.944 | 0.032⁎ |
| MSS | 298 | 93.70 | 236 | 94.80 | 23 | 79.30 | 52 | 94.50 | ||||
| T | ||||||||||||
| Tis-T1 | 20 | 6.20 | 10 | 4.00 | 0 | 0.00 | 2 | 3.60 | 0.055 | 0.124 | 0.518 | 0.685 |
| T2 | 40 | 12.50 | 31 | 12.40 | 1 | 3.40 | 3 | 5.50 | ||||
| T3 | 242 | 75.40 | 178 | 72.10 | 23 | 79.30 | 43 | 78.20 | ||||
| T4 | 19 | 5.90 | 31 | 12.40 | 5 | 17.20 | 7 | 12.70 | ||||
| N | ||||||||||||
| N0 | 178 | 55.50 | 136 | 54.40 | 17 | 58.60 | 32 | 58.20 | 0.353 | 0.656 | 0.175 | 0.934 |
| N1 | 94 | 29.30 | 86 | 34.40 | 6 | 20.70 | 13 | 23.60 | ||||
| M | ||||||||||||
| M0 | 271 | 84.16 | 212 | 84.80 | 23 | 79.30 | 37 | 67.30 | 0.012⁎ | 0.002⁎ | 0.002⁎ | 0.247 |
| M1 | 50 | 15.53 | 38 | 15.20 | 6 | 20.70 | 18 | 32.70 | ||||
| TNM staging | ||||||||||||
| I | 39 | 12.10 | 28 | 11.20 | 0 | 0.00 | 4 | 7.30 | 0.023⁎ | 0.007⁎ | 0.008⁎ | 0.246 |
| II | 126 | 39.30 | 100 | 40.00 | 16 | 55.20 | 23 | 41.80 | ||||
| III | 106 | 33.00 | 84 | 33.60 | 7 | 24.10 | 10 | 18.20 | ||||
| IV | 50 | 15.60 | 38 | 15.20 | 6 | 20.70 | 18 | 32.70 | ||||
| Tumor grade | ||||||||||||
| Grade 3 | 46 | 14.40 | 49 | 19.70 | 10 | 34.50 | 16 | 29.10 | 0.009⁎ | 0.019⁎ | 0.074 | 0.871 |
| Grade 2 | 200 | 62.50 | 159 | 63.90 | 13 | 44.80 | 26 | 47.30 | ||||
| Grade 1 | 74 | 23.10 | 41 | 16.50 | 6 | 20.70 | 13 | 23.60 | ||||
| Perineural invasion | ||||||||||||
| No | 293 | 92.70 | 234 | 94.40 | 26 | 89.70 | 52 | 94.50 | 0.712 | 0.625 | 0.956 | 0.408 |
| Yes | 23 | 7.30 | 14 | 5.60 | 3 | 10.30 | 3 | 5.50 | ||||
| Lymphovascular invasion | ||||||||||||
| No | 290 | 92.40 | 229 | 92.00 | 25 | 86.20 | 50 | 90.90 | 0.705 | 0.713 | 0.796 | 0.508 |
| Yes | 24 | 7.60 | 20 | 8.00 | 4 | 13.80 | 5 | 9.10 | ||||
⁎
P-values≤0.05.