Table 3.
Univariate and multivariate analyses of different prognostic parameters regarding to OS of the CRC patients.
| Univariate analysis |
Multivariate analysis |
|||
|---|---|---|---|---|
| Parameters | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age (<60 vs. ≥ 60 years) | 0.690 (0.464,1.027) | 0.068 | ||
| Gender (Female vs. Male) | 0.911 (0.609,1.363) | 0.649 | ||
| Histological grade | 0.610 (0.446,0.834) | 0.002⁎ | 0.754 (0.517,1.100) | 0.142 |
| CEA level (>5 ng/ml vs. ≤5 ng/ml) | 3.512 (2.280,5.408) | <0.001⁎ | 1.510 (0.914,2.496) | 0.108 |
| CA19–9 level (>37 ng/ml vs. ≤37 ng/ml) | 5.137 (3.440,7.672) | <0.001⁎ | 2.130 (1.285,3.532) | 0.003⁎ |
| CA12–5 level (>35 ng/ml vs. ≤35 ng/ml) | 3.251 (2.006,5.271) | <0.001⁎ | 1.401 (0.783,2.505) | 0.256 |
| Tumor location | 0.003⁎ | 0.405 | ||
| Proximal colon | 2.281 (1.359,3.830) | 0.002⁎ | 1.203 (0.663,2.183) | 0.544 |
| Distal colon | 1.963 (1.230,3.133) | 0.005⁎ | 1.419 (0.852,2.365) | 0.179 |
| Rectum | 1 | 1 | ||
| TNM stage | 3.731 (2.864,4.861) | <0.001⁎ | 2.153 (1.459,3.178) | <0.001⁎ |
| HER2 (Negative vs Positive) | 1.31 (0.854,2.008) | 0.216 | ||
| KI-67 (Negative vs Positive) | 1.485 (0.91,2.424) | 0.114 | ||
| MSI status (dMMR vs pMMR) | 0.286 (0.07,1.158) | 0.079 | ||
| Perineural invasion (Yes vs no) | 3.109 (1.864,5.184) | <0.001⁎ | 0.974 (0.485,1.958) | 0.941 |
| Lymphovascular invasion (Yes vs no) | 2.650 (1.504,4.668) | 0.001⁎ | 1.952 (1.068,3.565) | 0.03⁎ |
| Chemotherapy or radiotherapy (Yes vs No) | 1.426 (0.953,2.133) | 0.085 | 0.476 (0.294,0.771) | 0.003⁎ |
| Radical Surgery (No vs Yes) | 11.592(7.804,17.217) | <0.001⁎ | 3.526 (1.891,6.576) | <0.001⁎ |
| Mutations status | 0.001⁎ | 0.001⁎ | ||
| KRAS/PIK3CA wild-type | 1 | 1 | ||
| PIK3CA mut alone | 1.246 (0.444,3.496) | 0.677 | 0.660 (0.219,1.994) | 0.462 |
| KRAS mutation in exon 2 | 2.147 (1.395,3.303) | 0.001⁎ | 2.185 (1.338,3.569) | 0.002⁎ |
| KRAS mutation in exon 3 or 4 | 0.451 (0.109,1.870) | 0.272 | 0.868 (0.206,3.669) | 0.848 |
| Coexistence of PIK3CA mutant and KRAS mutation in exon 2 | 1.786 (0.861–3.704) | 0.119 | 1.080 (0.486–2.398) | 0.850 |
| Coexistence of PIK3CA mutant and KRAS mutation in exon 3 or 4 | 8.050 (1.926,33.644) | 0.004⁎ | 10.505 (2.304–47.905) | 0.002⁎ |
Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using univariate or multivariate Cox proportional hazards regression in SPSS 20.0. P-values were calculated using univariate or multivariate Cox proportional hazards regression in SPSS 20.0. P-values <0.05 were considered to indicate statistical significance.
⁎
P < 0.05.