Aerosol chemistry. A. Reduction in the yields of HPHCs in CHTP 1.2 aerosol relative to 3R4F mainstream smoke (per stick) [6]. B. As in A, but on a per mg nicotine basis. C. Reduction in the yields of HPHCs in THS 2.2 aerosol relative to 3R4F mainstream smoke (per stick, THS 2.2 D2) [56]. D. As in C, but on a per mg nicotine basis. HPHC, harmful and potentially harmful constituents; THS, Tobacco Heating System; CHTP, Carbon Heated Tobacco Product.