Fig. 10.

Cardiovascular effects in vivo. A. Percentage of atherosclerotic plaque area (planimetry): atherosclerotic plaque area as percentage of the total aortic arch area. Data are mean ± SEM. *p value vs. sham < 0.05; #p value vs. 3R4F < 0.05. B. Atherosclerotic plaque volume measured by micro-CT. Note: The sites of measurements might differ between the two studies (two different CROs). C. Number of DEGs in the left heart ventricle tissue (false discovery rate-adjusted p value < 0.05). See Fig. 3 legend for details on the study and group labeling. CT, computed tomography; DEG, differentially expressed gene; SEM, standard error of the mean; THS, Tobacco Heating System; CHTP, Carbon Heated Tobacco Product.