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Brains in persons with AD or MCI have elevated HNE-bound proteins compared to aged-matched controls. In the middle ring, various functional pathways are noted that are damaged secondary to covalent HNE binding to Cys, His, or Lys residues. Other processes and pathways also are affected. The outer ring indicates the resulting dysfunctions that are seen in AD and MCI brain as a consequence of HNE-bound proteins in the various pathways noted. See text for more details.
