Table 1.
Study population by clinical OI type
All OI types | OI-I | OI-III | OI-IV | P | |
---|---|---|---|---|---|
N (m/f) | 144 (76/68) | 55 (34/21) | 28 (12/16) | 61 (30/31) | 0.20 |
Age (years) | 18.3 (10.7) | 19.6 (14.2) | 18.5 (6.1) | 17.0 (8.3) | 0.44 |
History of Bisphosphonate Treatment (N, %) | 114 (79%) | 29 (53%) | 27 (96%) | 58 (95%) | <0.001 |
Height z-score | −3.3 (3.0) | −0.8 (1.0)b,c | −8.0 (1.8)a,c | −3.5 (1.7)a,b | <0.001 |
Mean Hand Bone Length z-score | −1.1 (1.4) | −0.2 (1.0)b,c | −2.9 (1.2)a,c | −1.2 (1.0)a,b | <0.001 |
Pattern Variability Index | 0.46 (0.32) | 0.42 (0.32) | 0.52 (0.36) | 0.47 (0.31) | 0.36 |
Results are shown as N or mean (SD). P values indicate significance of the difference between OI types (ANOVA or chi square tests, as appropriate). Superscripts indicate significant differences (Bonferroni’s adjustment) to
OI type I,
OI type III,
OI type IV.