Table 1.

Study population by clinical OI type

	All OI types	OI-I	OI-III	OI-IV	P
N (m/f)	144 (76/68)	55 (34/21)	28 (12/16)	61 (30/31)	0.20
Age (years)	18.3 (10.7)	19.6 (14.2)	18.5 (6.1)	17.0 (8.3)	0.44
History of Bisphosphonate Treatment (N, %)	114 (79%)	29 (53%)	27 (96%)	58 (95%)	<0.001
Height z-score	−3.3 (3.0)	−0.8 (1.0)^b,c	−8.0 (1.8)^a,c	−3.5 (1.7)^a,b	<0.001
Mean Hand Bone Length z-score	−1.1 (1.4)	−0.2 (1.0)^b,c	−2.9 (1.2)^a,c	−1.2 (1.0)^a,b	<0.001
Pattern Variability Index	0.46 (0.32)	0.42 (0.32)	0.52 (0.36)	0.47 (0.31)	0.36

Results are shown as N or mean (SD). P values indicate significance of the difference between OI types (ANOVA or chi square tests, as appropriate). Superscripts indicate significant differences (Bonferroni’s adjustment) to

^a:

OI type I,

^b:

OI type III,

^c:

OI type IV.