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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Drug Alcohol Depend. 2020 Aug 5;215:108215. doi: 10.1016/j.drugalcdep.2020.108215

Figure 2.

Figure 2.

Impact of adolescent nicotine exposure on active and inactive lever pressing during nicotine IVSA in adult male Sprague-Dawley rats. All data are presented as mean±standard error of mean. (a) Saline pre-exposed rats do not significantly differ on active compared to inactive lever presses on an FR1, FI1, and PR schedule of reinforcement. (b) Nicotine pre-exposed rats learn to significantly discriminate between active and inactive levers on an FR1, FI1, and PR schedule of reinforcement. * indicates significant post hoc differences following significant interaction (p<0.05). $ indicates significant effect of group in the absence of an interaction.