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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Gastroenterology. 2020 Jun 20;159(3):849–863. doi: 10.1053/j.gastro.2020.04.077

Figure 2. Intestinal epithelial tight junctions.

Figure 2.

Intestinal epithelial tight junctions are composed of 3 classes of transmembrane proteins that associate with scaffolding proteins that link to the actin cytoskeleton. The transmembrane proteins include occludin, claudins, and JAMA. Occludin and claudin proteins have cytoplasmic N- and C-termini and 4 transmembrane domains. JAMA has a cytoplasmic C-terminus and 2extracellular V-type Ig domains. Importantly, JAMA can dimerize in cis (molecules on the same cell) and in trans (molecules on adjacent cells).