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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Arch Toxicol. 2020 Jul 16;94(10):3515–3526. doi: 10.1007/s00204-020-02844-w

Figure 2. Differential changes in striatal mRNA expression of autophagy-related genes after METH SA and footshocks.

Figure 2.

METH SA and footshocks are associated with increased Atg2a (A), Atg5 (B) and Atg12 (E) mRNA levels in the dorsal striatum of SR rats in comparison to control and SS rats. (C and D) Striatal Atg7 and Atg10 mRNA levels show no significant changes in any of the group. (F) Striatal Atg13 mRNA expression was increased only in YSR rats. (G) Striatal Atg14 mRNA expression showed increases in both YSR and SR rats. (H) Atg16L mRNA levels were increased only in SR rats. The values in bar graphs represent means ± SEM (n = 7–10 animals per group). Key to statistics: *, **, *** = p < 0.05, 0.01, 0.001, respectively, in comparison to control rats; #, ##p < 0.05, 0.01, respectively, in comparison to SR rats; $, $ $ p < 0.05, 0.01, respectively, in comparison to YSR.