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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Bone. 2020 Jul 27;140:115549. doi: 10.1016/j.bone.2020.115549

Figure 3.

Figure 3.

Structural features of BMP intracellular kinase domains. A) Structure of type I receptor Alk6 kinase domain (3MDY) with GS domain (gold), L45 loop (green), αC (blue), and Activation loop (red) highlighted and labelled [189]. B) Structure of type II receptor BMPRII kinase domain (3G2F) with αC (blue) and Activation loop (red) highlighted and labelled [192]. C) & D) Sequence conservation of intracellular kinase domains. Using ConSurf software and Clustal sequence alignment sequence conservation of type I (C) and type II (D) receptors is shown [60–64]. Conservation is colored from dark gray (variable) to yellow (conserved) for type I receptors and orange (conserved) for type II receptors.