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. Author manuscript; available in PMC: 2021 Jan 20.
Published in final edited form as: Nat Chem Biol. 2020 Jul 20;16(10):1052–1061. doi: 10.1038/s41589-020-0584-z

Extended Data Fig. 5.

Extended Data Fig. 5

A. Heat map of top 100 genes upregulated in HEK293T cells treated for 4 hrs with IXA4 (10 μM) compared to dox-inducible XBP1s or TMP-stabilized DHFR.ATF6 in HEK293DAX cells treated with doxycycline (1 μg/mL) or TMP (10 μM) for 4 hr.

B. Heat map of top 100 genes upregulated in HEK293T cells treated for 4 hrs with IXA6 (10μM) compared to dox-inducible XBP1s or TMP-stabilized DHFR.ATF6 in HEK293DAX cells treated with doxycycline (1 μg/mL) or TMP (10μM) for 4 hrs.

C. Heat map of top 100 genes upregulated in HEK293T cells treated for 4 hr with IXA1 (10 μM) compared to dox-inducible XBP1s or TMP-stabilized DHFR.ATF6 in HEK293DAX cells treated with doxycycline (1 μg/mL) or TMP (10 μM) for 4 hrs.