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. Author manuscript; available in PMC: 2021 Jan 20.
Published in final edited form as: Nat Chem Biol. 2020 Jul 20;16(10):1052–1061. doi: 10.1038/s41589-020-0584-z

Extended Data Fig. 9.

Extended Data Fig. 9

A. Graph showing qPCR of the XBP1 target gene DNAJB9 in SHSY5Y cells transiently expressing empty vector (Mock) or Swedish mutant APP (APPSW) in the presence or absence of IXA4 (10 μM) for 72 hrs. Error bars show SE for n= 2. Statistics calculated from one-tailed Student’s t-test. *p<0.05, **p<0.01.

B. Graph showing qPCR of the PERK target gene CHOP in SHSY5Y cells transiently expressing empty vector (Mock) or APPSW in the presence or absence of IXA4 (10 μM) for 72 hrs. Error bars show SE for n= 2.

C. Representative histograms showing TMRE staining of SHSY5Y cells transiently expressing empty vector (Mock) or wild-type APP (APPWT) in the presence or absence of IXA4 (10 μM) for 72 hrs.