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PC progression in the tamoxifen-induced iKC mouse model. Pancreatic tissues were isolated from corn-oil- and tamoxifen-treated iKC mice at 4, 10, 20, 30 and 50 weeks of age. The tissues were paraffin-embedded and formalin-fixed. Sections (4 µm) were stained with H&E. Pre-cancerous lesions (PanINs) were not detected at any point in corn-oil-treated animals. By 4 weeks after tamoxifen injection, PanINs had formed; they progressed to high-grade lesions by 30 weeks and PC by 50 weeks.
