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. 2020 Sep 7;9(9):bio052878. doi: 10.1242/bio.052878

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Expression of acinar marker amylase and ductal marker cytokeratin-19 in iKC mouse model. IHC studies using CK19 and amylase antibodies were performed on pancreatic tissues isolated from both corn-oil- and tamoxifen-treated iKC mice. (A) Expression of CK19 was not detected at any time point in the corn-oil-treated mouse tissues (lower row). In contrast significant upregulation of CK19 was detected in tamoxifen-induced mouse tissues (upper row). (B) The expression of amylase was observed in the acinar compartment of the pancreas (upper and lower panels) and the transdifferentiated ductal compartment (upper panel). (C) Immunofluorescence confocal microscopy revealed that amylase and CK19 were coexpressed in ducts undergoing transdifferentiation in the tamoxifen-induced mice.