Table 1.
MTHFR Genotype and Allele frequnecies and homocysteine levels
| C667T Mutation (N = 124) | A1298C Mutation (N = 124) | MS A2756G Mutation (N = 69) | CBS T833C Mutation (N = 69) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype frequencies % (n) | ‘T’ allele frequency % | Genotype frequencies % (n) | ‘C’ allele frequency % | Genotype frequencies % (n) | ‘G’ allele frequency % | Genotype frequencies % (n) | ‘C’ allele frequency % | |||||||||
| CC | CT | TT | AA | AC | CC | AA | AG | GG | TT | TC | CC | |||||
| Hcys levels between 0 – 10 μmol/L | 81.5 (22) | 18.5 (5) | 0 | 9.3 | 37 (10) | 33.3 (9) | 29.6 (8) | 46.3 | 53.3 (8) | 20 (3) | 26.7 (4) | 36.7 | 86.7 (13) | 13.3 (2) | 0 | 6.7 |
| Hcys levels between 10 – 15 μmol/L | 78.3 (18) | 21.7 (5) | 0 | 10.9 | 26.1 (6) | 60.9 (14) | 13 (3) | 43.5 | 66.7 (8) | 33.3 (4) | 0 | 16.7 | 83.3 (10) | 16.7 (2) | 0 | 8.3 |
| Hcys levels between 15 – 30 μmol/L | 71.9 (23) | 21.9 (7) | 6.2 (2) | 17.2 | 53.1 (17) | 40.6 (13) | 6.25 (2) | 26.56 | 40.9 (9) | 54.6 (12) | 4.5 (1) | 31.8 | 86.4 (19) | 13.6 (3) | 0 | 6.8 |
| Hcys levels between > 30 μmol/L | 69.1 (29) | 16.7 (7) | 14.3 (6) | 22.6 (p = 0.00069)* | 40.5 (17) | 45.2 (19) | 14.3 (6) | 36.9 | 30 (6) | 50 (10) | 20 (4) | 45 (p < 0.002)* | 95 (19) | 5 (1) | 0 | 2.5 (p = 0.0131)* |
| Total (n = 124) | 74.2 (92) | 19.4 (24) | 6.5 (8) | 16.1 (p = 0.0015)* | 40.3 (50) | 44.4 (55) | 15.3 (19) | 37.5 | 45 (31) | 42 (29) | 13 (9) | 34.1 | 88.4 (61) | 11.6 (8) | 0 | 5.8 |
*Hardy–Weinberg equilibrium showed significance