FIG. 3.

CNS-derived EVs express molecular cargo involved in a wide variety of cellular functions. Proteomic analysis of microvesicles isolated from the CSF of patients with TBI revealed differential expression of proteins involved in a wide variety of signaling pathways.⁸¹ These data provide rationale for the analysis of multiple types of EV cargo for assessment of underlying mechanisms of TBI pathology. CSF, cerebrospinal fluid; CNS, central nervous system; EV, extracellular vesicle; TBI, traumatic brain injury.