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Conformational changes of ICL2 from inactive to active state. (A and B) 1H-13C HSQC spectra of K14034.52 (A) and K1474.39 (B). The 1D slices of corresponding 1H-13C HSQC spectra in H dimension are shown at the bottom. The local environment of the two probes are shown by side views in inactive (gray, C, E) and active (green, D, F) conformations. Gαs is shown in purple (D). The agonist BI-167107 is abbreviated by BI.
