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. 2020 Aug 31;117(37):23096–23105. doi: 10.1073/pnas.2009786117

Fig. 5.

Fig. 5.

Comparison of conformational changes in β2AR coupled to Gs or Gi1. BI is short for BI-167107. (A–H) The 1H-13C HSQC spectra of the eight probes from TM1 to H8. The eight probes are K601.59 (A), K14034.52 (B), K1474.39 (C), K2275.56 (D), K2676.29 (E), K2736.35 (F), R328K7.55 (G), and R333K8.51 (H). For each probe, the overlay of the 1H-13C HSQC spectra of agonist-bound β2AR (green) and β2AR-GsEMPTY (blue) are shown at the top, followed by the comparison of the 1H-13C HSQC spectra of agonist-bound β2AR (green) and β2AR-Gi1EMPTY (pink), then by the overlay of β2AR-GsEMPTY (blue) and β2AR-Gi1EMPTY (pink). The 1D slices of corresponding 1H-13C HSQC spectra in H dimension are shown at the bottom.