Table 3.

Brain and Plasma Levels of TBTIs 1–6

	Brain (nM)		Brain (nM)		Plasma (nM)
	Total		Parenchyma
Name	24 h	72 h	24 h	72 h	24 h	72 h
13C3	0.382	0.445	0.444	0.402	539	495
TBTI1	4.42	0.646	2.095	0.5735	160	3.55
TBTI2	4.12	1.55	1.72	0.94	95	25.1
TBTI3	5.08	2.23	3	1.31	112	6.23
TBTI4	2.61	2.24	1.55	1.79	513	341
TBTI5	1.36	1.44	ND	ND	593	447
TBTI6	3.61	2.05	2.91	1.89	618	452

Single i.v. injection in C57BL/6J mice (70 nmol/kg, n = 3 mice per group). ND, not determined; brain total, cortex homogenate; brain parenchyma, membrane-unbound fraction (supernatant).