Table 1.
Developmental stage-specific expression of immuno-histological protein markers in the neurogenic niche of adult hippocampus.
| Stage 1 (Neural stem cell markers) | Stage 2 (Progenitor intermediate cell forms markers) | Stage 3 (Migration/ Immature granule cell markers) | Stage 4 (Axonal & dendritic targeting/Early maturation markers) | Stage 5 (Synaptic integration/Late maturation markers) | |
|---|---|---|---|---|---|
| NESTIN, BLBP, GFAP, SOX1, 2 & 4 | TBR2#, MCM2, PAX6 | NEUROD1, DCX*, PSA NCAM | STMN2, SEMA3C, Calretinin**, (CALB2), TUBB3*** | MAP2, Calbindin (CALB1), NEUN****#, | |
| Pan neuronal lineage marker | PROX1 | ||||
| Cell proliferation markers | KI67#, PCNA | ||||
| Gliogenesis markers | OLIG2, Vimentin#, S100B, PDGFRA, NG2 | ||||
| Vasculogenesis markers | VEGFA, FGF2 | ||||
| Apoptosis markers | BAX, TP53 | ||||
*Pan neuronal lineage marker (expressed in Stage 2–5), *Also expressed in Stage 4, **Also expressed in Stage 5, ***A postmitotic neuronal lineage marker, also expressed in stage 3 and 5, ****\Also expressed in stage 4.
#Alternative gene names:TBR2 or EOMES, KI67 or MKI67, NEUN or RBFOX3, Vimentin or VIM.