Table 3.

Cost-effectiveness of Intermittent PPI Treatment.

Author	Year	Methodology	Outcome	Conclusion	Limitation
Goeree et al11 (Canada)	2002	• Strategy C: Intermittent PPI. Acute treatment with a PPI (eg, omeprazole 20 mg or lansoprazole 30 mg once daily) for 4 weeks and no further treatment with prescription medications until recurrence.	• Using a decision-analytic model, the calculated incremental cost per QALY in CDN$ is 12 206.	• Incremental cost per QALY CDN$12 206	• For the symptom relief and symptom recurrence meta-analyses, a majority of studies relied on endoscopy results as a primary entry criterion and outcome measure, whereas symptoms were typically a secondary criterion. • The authors used moderate-to-severe heartburn as primary measure of GERD symptoms. • 1-year time horizon for the study may be too short to capture long-term complications such as Barrett esophagus or esophageal stricture. • This study used inputs (ie, costs), which are specific to the province of Ontario only.

Note. PPI = proton pump inhibitor; QALYs = quality-adjusted life in years; GERD = gastroesophageal reflux disease.