Table 1.
Patient Characteristics.
| Baseline characteristics—no. (%) | N = 24 |
|---|---|
| Age, yearsa | 74.1 [61.8-87.9] |
| Female gender | 16 (66.7) |
| Anti-thrombotic therapy | |
| Aspirin | 12 (50) |
| Clopidogrel | 2 (8.3) |
| Warfarin | 2 (8.3) |
| Ischemic Stroke Presentation and Management—no. (%) | |
| NIHSS Scorea | 12 [5 –19] |
| Stroke onset to rt-PA treatment time, hoursa | 2.2 [1.6–2.7] |
| Intravenous rt-PA—no. (%) | 24 (100) |
| rt-PA initiated at OSH—no. (%) | 20 (83.3) |
| Mechanical recanalization—no. (%) | 4 (16.7) |
| Intra-arterial rt-PA—no. (%) | 1 (4.2) |
| Laboratory Parameters Pre rt-PAa | |
| Platelets, k/mm3 | 203 [161–303] |
| INR | 1 [1–1.1] |
| PT, seconds | 12.6 [11.2–13.4] |
| aPTT, seconds | 28.4 [26.3–29.6] |
| Glucose | 159 [110–199] |
| Hemorrhage Presentation—no. (%) | |
| Symptom onset at OSH | 8 (33.3) |
| Time from rt-PA to hemorrhage confirmation, hoursa,b | 4.6 [3.3–6.0] |
| Hemorrhage type | |
| ICH | 22 (91.7) |
| GIc | 2 (8.3) |
| Groin puncture site | 1 (4.2) |
| Time from hemorrhage confirmationb to fibrinogen concentrate administration, hoursa | 1.2 [0.5–2.3] |
| Laboratory Parameters Post rt-PA Prior to Fibrinogen Concentratea | |
| Fibrinogen, mg/dL | 256 [130–347] |
| Platelets, k/mm3 | 197 [150–287] |
| INR | 1.2 [1.1–1.6] |
| PT, seconds | 15.1 [14.4–18.9] |
| aPTT, seconds | 33.4 [27.8–39.6] |
| Hematocrit, % | 37.4 [34.1–41.4] |
| Hemoglobin, mg/dL | 12.6 [11–13.9] |
OSH: Outside hospital; ICH: Intracerebral Hemorrhage; GI: Gastrointestinal.
a Data presented as median [interquartile range.
b On radiographic imaging (ICH) or clinical presentation (gastrointestinal, groin puncture hemorrhage).
c One patient had concurrent ICH and GI bleed.