P |
Population: Adults (>18 years of age), cancer patients with an identified stage of cachexia (according to Fearon et al,21 2011), or animal models with a cachexia-inducing tumor implanted |
I |
Intervention: Sole, repetitive exercise performed at least for 7 days in a controlled (ie, supervised) exercise protocol (excluding voluntary exercise trials) |
C |
Comparison: Human or animal tumor hosts without structured exercise influence (also excluding studies which performed unilateral exercise and studies using the contralateral body part as control) |
O |
Outcomes: Primary: total body mass; Secondary: muscle mass and muscle cross-sectional area |
S |
Study design: Randomized-controlled trials or controlled trials |