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. 2020 Aug 10;39(18):e103932. doi: 10.15252/embj.2019103932

Figure EV1. Defining the region for oncogenic RNF43 truncations.

Figure EV1

  1. RNF43 stainings of cells of the experiment shown in Fig 1E. Scale bar represents 10 μm.
  2. β‐catenin‐mediated reporter activity in HEK293T double knockout (dKO) RNF43/ZNRF3 (R/Z) cells expressing RNF43 WT and oncogenic RNF43 (R519X) after treatment with DMSO or the PORCN inhibitor IWP‐2 (5 μM; o/n). Average β‐catenin‐mediated reporter activities ± s.d. in n = 2 independent wells are shown.
  3. β‐catenin‐mediated reporter activity in HEK293T cells expressing the indicated RNF43 truncations in the absence of Wnt3a. Average β‐catenin‐mediated reporter activities ± s.d. in n = 2 independent wells are shown.
Data information: WT; wild‐type.