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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Jul 23;40(9):e240–e255. doi: 10.1161/ATVBAHA.120.314935

Figure 5. Overexpressing Kir2.1 in endothelium restores Kir flow- and HEPIII-sensitivity.

Figure 5.

Representative shear-induced IKir recordings from A) control and B) heparanse III treated (HEPIII) lean mouse endothelial cells (ECs). Representative IKir recordings from ECs isolated from obese mouse mesenteric arteries exposed to C,D) Empty-adenovirus (Em-AV) or E,F) VE-Cadherin-WT-Kir2.1-AV with and without HEPIII treatment. G) Group data (n = 7–12 cells from 4–8 mice/group, *p<0.05). Data from males and female obese mice were combined. Current Density, CD.