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. Author manuscript; available in PMC: 2020 Sep 21.
Published in final edited form as: Lab Invest. 2009 Mar 30;89(6):676–694. doi: 10.1038/labinvest.2009.27

Figure 10.

Figure 10

Proapoptosis by downregulation of ERK signals. (a) The constitutively active GPCR-mediated ERK signals in apoptotic parent HL-60 cells at 12 and 24 h after thapsigargin treatment were detected by western blot. Representative cell cycle result (b) or calculated apoptotic ratio (c) at several time points in the presence of control PBS (thin line (b) or white column (c)) compared with in the presence of PTX (thin dot line (b) or black column (c)), ERK inhibitor (PD98059) (thick line (b) or hatched column (c)), and p38MAPK inhibitor (SB203580) (thick dot line (b) or dotted column (c)) by FACS. Data are mean values±s.d. (*P<0.05, **P<0.01).