Table 2.
Transporters as cancer therapeutic targets. Silencing and CrispR ko data from https://Depmap.org are shown. Transporters are listed by solute carrier number and common name. Four widely used nontransporter targets are listed for comparison at the end of the table. Transporters that are expressed consistently across all cell lines are shown as (+) for low expression levels, (++) for elevated expression levels, (+++) for high expression levels. N.d. not determined.
| Solute Carrier | Common Name | Cell Lines Affected by CrispR | Cell Lines Affected by Silencing | Pan-Cancer Expression |
|---|---|---|---|---|
| SLC1A1 | EAAT3 | 1/769 | 0/710 | |
| SLC1A2 | EAAT2 | 3/769 | 0/712 | |
| SLC1A3 | EAAT1 | 1/769 | 4/671 | |
| SLC1A4 | ASCT1 | 1/769 | n.d. | + |
| SLC1A5 | ASCT2 | 176/769 | 5/710 | +++ |
| SLC1A6 | EAAT4 | 4/769 | 0/547 | |
| SLC1A7 | EAAT5 | 0/769 | 1/547 | |
| SLC3A1 | rBAT | 0/769 | 6/547 | |
| SLC3A2 | 4F2hc | 335/769 | 2/547 | ++ |
| SLC6A5 | GlyT2 | 0/769 | 0/547 | |
| SLC6A7 | PROT | 6/769 | 0/547 | |
| SLC6A9 | GlyT1 | 2/769 | 0/547 | |
| SLC6A14 | ATB0,+ | 0/721 | 14/711 | |
| SLC6A15 | B0AT2 | 1/769 | 0/708 | |
| SLC6A17 | NTT4/B0AT3 | 7/769 | 0/547 | |
| SLC6A18 | XT2/B0AT3 | 0/769 | 0/710 | |
| SLC6A19 | B0AT1 | 3/769 | 27/712 | |
| SLC6A20 | SIT1 | 0/769 | 0/708 | |
| SLC7A1 | CAT-1 | 135/769 | 18/711 | + |
| SLC7A2 | CAT-2 | 0/769 | 9/501 | |
| SLC7A3 | CAT-3 | 0/721 | 0/547 | |
| SLC7A4 | CAT-4 | 2/769 | 0/501 | |
| SLC7A5 | LAT1/4F2hc | 416/769 | 1/547 | +++ |
| SLC7A6 | y+LAT2/4F2hc | 5/769 | 0/285 | ++ |
| SLC7A7 | y+LAT1/4F2hc | 0/769 | 1/708 | |
| SLC7A8 | LAT2/4F2hc | 1/769 | 1/712 | |
| SLC7A9 | b0,+AT/rBAT | 1/769 | 0/711 | |
| SLC7A10 | Asc-1/4F2hc | 2/769 | 0/547 | |
| SLC7A11 | xCT/4F2hc | 8/769 | 2/710 | ++ |
| SLC7A13 | AGT1/rBAT | 4/769 | 0/547 | |
| SLC7A14 | c | 0/769 | 12/605 | |
| SLC16A10 | TAT1 | 1/769 | 0/547 | |
| SLC17A6 | VGLUT2 | 1/769 | 0/547 | |
| SLC17A7 | VGLUT1 | 2/769 | 5/547 | |
| SLC17A8 | VGLUT3 | 0/769 | 1/547 | |
| SLC25A2 | ORC2 | 0/769 | 4/547 | |
| SLC25A12 | AGC1 | 1/769 | 0/710 | |
| SLC25A13 | AGC2 | 8/769 | 0/710 | |
| SLC25A15 | ORC1 | 0/769 | 4/712 | |
| SLC25A18 | GC2 | 24/769 | 0/501 | |
| SLC25A22 | GC1 | 99/769 | 0/710 | |
| SLC25A44 | BCAA | 0/769 | 0/343 | |
| SLC32A1 | VIAAT | 1/769 | 1/547 | |
| SLC36A1 | PAT1 | 0/769 | 11/710 | |
| SLC36A2 | PAT2 | 0/769 | 2/547 | |
| SLC36A3 | PAT3 | 0/769 | 0/547 | |
| SLC36A4 | PAT4 | 0/769 | 0/547 | |
| SLC38A1 | SNAT1 | 13/769 | 0/710 | +++ |
| SLC38A2 | SNAT2 | 161/769 | 1/547 | +++ |
| SLC38A3 | SNAT3 | n.d. | 1/547 | |
| SLC38A4 | SNAT4 | 1/769 | 0/547 | |
| SLC38A5 | SNAT5 | 3/721 | 0/547 | |
| SLC38A6 | SNAT6 | 2/769 | 1/710 | + |
| SLC38A7 | SNAT7 | 2/769 | 17/547 | + |
| SLC38A8 | SNAT8 | 0/769 | n.d. | |
| SLC38A9 | SNAT9 | 0/769 | 16/343 | + |
| SLC38A10 | SNAT10 | 9/769 | 1/597 | |
| SLC38A11 | SNAT11 | 13/769 | 1/597 | |
| SLC43A1 | LAT3 | 0/769 | 2/547 | + |
| SLC43A2 | LAT4 | 0/769 | n.d. | |
| SLC43A3 | EEG | 1/796 | 0/547 | |
| Nontransporters | ||||
| DHFR | 520/769 | 0/710 | ||
| NRAS | 49/769 | 31/712 | ||
| BRAF | 76/769 | 45/712 | ||
| MTOR | 767/769 | 347/712 |