Table 1.

Role and target of miRNAs in BMSC regulation.

MiRNA	Relative Expression	Role	Target	References
MiR-214	Upregulation	Inhibits osteoblast differentiation and enhances adipogenesis	β-catenin, FGFR1/FGF, JNK, and p38	[20,36]
MiR-23b	Upregulation	Reduces osteogenesis	Runx2	[21]
Let-7	Upregulation	Stimulates osteogenic differentiation of MSCs	HMGA2	[23]
MiR-339	Upregulation	Impairs osteogenic differentiation BMSCs	DLX5	[26]
MiR-223	Downregulation	Stimulates osteogenic differentiation of hMSCs	DHRS3	[27]
MiR-31	Upregulation	Reduces osteogenic differentiation of BMSCs	Satb2 protein, osterix	[29,30]
MiR-449b-5p	Upregulation	Reduces BMSCs differentiation	Satb2	[31]
MiR-384-5p	Upregulation	Promotes senescence and decreases osteogenesis of rat BMSCs	Gli2	[32]
MiR-374b	Upregulation	Promotes osteogenic differentiation and fracture healing	PTEN	[33]
MiR-200a-3p	Upregulation	Impairs osteogenic differentiation of MSCs	L-glutaminase	[34]
MiR-206	Upregulation	Impairs osteogenic differentiation BMSCs	L-glutaminase	[35]