Table 4.

MiRNAs involved in osteoclast regulation.

MiRNA	Relative Expression	Role	Target	References
MiR-29	Upregulation	Regulates the formation of osteoclast	Calcr	[84]
MiR-31	Downregulation	Suppresses osteoclast formation and bone resorption	RhoA	[85]
MiR-29b	Upregulation	Lowers cell differentiation and function of osteoclasts	NAFTc-1	[86]
MiR-133a	Upregulation	Promotes osteoclastogenesis and bone loss in vivo	RANKL	[87]
MiR-218 and miR-618	Upregulation	Reduces osteoclastogenesis	TLR-4/MyD88/NF-κB signaling	[88]
MiR-31a-5p	Downregulation	Reduces osteoclasts differentiation and function	RhoA	[89]
MiR-214	Upregulation	Increases osteoclast activity	PTEN	[90]
MiR-539	Upregulation	Reduces osteoclastogenesis	Axin1	[91]