Table 10.
Role of miRNAs in osteoporosis osteoblasts.
| MiRNA | Relative Expression | Role | Target | References |
|---|---|---|---|---|
| MiR-320a | Upregulation | Promotes cell apoptosis in MC3T3-E1 | MAP9 | [121] |
| MiR-181c-5p and miR-497-5p | Upregulation | Promotes the differentiation and mineralization of hFOB1.19 and MC3T3-E1 | − | [122] |
| MiR-539 | Upregulation | Promotes proliferation and differentiation of osteoblasts | AXIN1 | [91] |
| MiR-140-3p | Upregulation | Suppresses MC3T3-E1 viability and differentiation | MCF2L | [124] |
| MiR-214-3p | Upregulation | Reduces osteoblast differentiation and bone formation in vivo | − | [125] |
| MiR-133a | Upregulation | Delays the healing of fractures | Runx2/BMP2 | [126] |