Figure 2.

The heart and lung weight and gross anatomical infract area by day 60 after AMI procedure. (A) The ratio of heart weight to tibial length, * vs. other groups with different symbols (†, ‡), p < 0.01. (B–E) Illustrating the morphological features (i.e., the total heart and the cross-section of the heart) of the heart and infarct zone (yellow dotted line) among the four groups. (F) Analytical result of gross anatomical infarct area, * vs. other groups with different symbols (†, ‡), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 10 for each group). Symbols (*, †, ‡) indicate significance (at 0.05 level). SC = sham-operated control; MT^DO = double knock out of matrix metalloproteinase (MMP)-9 and tissue plasminogen (tPA) in mice; B6 (i.e., wild type) = C57BL/6 mice. AMI = acute myocardial infarction.