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. 2020 Aug 27;21(17):6219. doi: 10.3390/ijms21176219

Figure 4.

Figure 4

Protein expressions of oxidative-stress and inflammatory biomarkers in LV myocardium by 60 days after AMI procedure. (A) Protein expression of NOX-1, * vs. other groups with different symbols (†, ‡), p < 0.0001. (B) Protein expression of NOX-2, * vs. other groups with different symbols (†, ‡), p < 0.0001. (C) Oxidized protein expression, * vs. other groups with different symbols (†, ‡), p < 0.0001. (Note: left and right lanes shown on the upper panel represent the protein molecular weight marker and control oxidized molecular protein standard, respectively). M.W. = molecular weight; DNP = 1-3 dinitrophenylhydrazone. (D) Protein expression of matrix metalloproteinase (MMP)-2, * vs. other groups with different symbols (†, ‡), p < 0.0001. (E) Protein expression of MMP-9, * vs. other groups with different symbols (†, ‡), p < 0.0001. (F) Protein expression of tumor necrosis factor (TNF)-α, * vs. other groups with different symbols (†, ‡), p < 0.0001. (G) Protein expression of phosphorylated nuclear factor (p-NF)-κB, * vs. other groups with different symbols (†, ‡), p < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡) indicate significance (at 0.05 level). SC = sham-operated control; MTDO = double knock out of matrix metalloproteinase (MMP)-9 and tissue plasminogen (tPA) in mice; B6 (i.e., wild type) = C57BL/6 mice. LV = left ventricular; AMI = acute myocardial infarction.