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. 2020 Aug 27;21(17):6219. doi: 10.3390/ijms21176219

Figure 6.

Figure 6

The fibrotic and collagen deposition areas in LV myocardium by 60 days after the AMI procedure. (A–D) The microscopic findings (100×) of Masson’s trichrome stain for identification of fibrotic areas (blue color). (E) Analytic result of the fibrotic areas, * vs. other groups with different symbols (†, ‡), p < 0.0001. (F–I) The microscopic findings (100×) of Sirius red stain for identification of collagen deposition areas (pink color). (J) Analytical result of the collagen deposition areas, * vs. other groups with different symbols (†, ‡), p < 0.0001. The scale bars in the right lower corner represent 100 µm. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡) indicate significance (at 0.05 level). SC = sham-operated control; MTDO = double knock out of matrix metalloproteinase (MMP)-9 and tissue plasminogen (tPA) in mice; B6 (i.e., wild type) = C57BL/6 mice. LV = left ventricular; AMI = acute myocardial infarction.