Skip to main content
. 2020 Aug 27;21(17):6219. doi: 10.3390/ijms21176219

Figure 7.

Figure 7

Infarct area and cellular level of DNA damage biomarkers in LV myocardium by 60 days after the AMI procedure. (A–D) The microscopic findings (100×) of H.E stain for identification of infarct areas. (E) Analytical result of infarct area * vs. other groups with different symbols (†, ‡), p < 0.0001. The scale bars in the right lower corner represent 100 µm. (F–I) The immunofluorescent (IF) microscopic findings (400×) for identification of positively-stained γ-H2AX+ cells (red color). (J) Analytical result of the number of γ-H2AX+ cells. The scale bars in the right lower corner represent 20 µm. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡) indicate significance (at 0.05 level). SC = sham-operated control; MTDO = double knock out of matrix metalloproteinase (MMP)-9 and tissue plasminogen (tPA) in mice; B6 (i.e., wild type) = C57BL/6 mice. LV = left ventricular; AMI = acute myocardial infarction.