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. 2020 Sep 17;2(3):zcaa023. doi: 10.1093/narcan/zcaa023

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© The Author(s) 2020. Published by Oxford University Press on behalf of NAR Cancer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — DNA damage induced by A3H Hap I. (A–C) The γH2AX foci detected by immunofluorescence microscopy in NCI-H1563 cells that were or were not transduced to express a dox-inducible A3H Hap I-Flag protein. Different cell treatment conditions were dox in non-transduced cells (Mock), dox treatment to induce A3H Hap I, but with transfection of a plasmid expressing UGI (Induced + UGI), transduced, but uninduced cells (Uninduced), and transduced and induced cells (Induced). The NCI-H1563 cells were analyzed 24 h after the treatment. Three representative images are shown. (D) Results were quantified and plotted as a histogram. Foci/cell are represented as 1–5 (Bin 5), 6–10 (Bin 10), 11–15 (Bin 15) and ≥15 (More) γH2AX foci/cell.