Fig. 3.

Structural covariance with left medial frontal seed. (A) Localization of the left medial prefrontal seed (x = −9, y = 47, z = 11) used for the structural covariance analysis. (B) interactions between the degree of structural covariance of changes in cortical thickness in the left medial prefrontal seed and percentage of time spent with positive symptoms during the first interscan interval, on changes in cortical thickness across all other vertices of the cortex. Positive interactions between changes in cortical thickness within the seed region and unremitted psychotic symptoms were found within a large cluster encompassing left dorsolateral and ventrolateral prefrontal cortex. (C) To illustrate the direction of the interaction effect in (B) between 2 continuous variables, patients were split into 2 subgroups (unremitted n = 61 and remitted n = 19). As can be seen in the figure, the unremitted group seems to be driving the positive association in structural covariance between cortical thinning in the left medial prefrontal seed and individual differences in the thinning of the cluster within left lateral prefrontal cortex depicted.