Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 3;21(17):6451. doi: 10.3390/ijms21176451

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Modern Correa pathway of intestinal-type gastric carcinogenesis, with risk factors and host mechanisms in green, molecular genetics in blue, and preventive factors in yellow. As histological changes progress, antioxidant systems and DNA repair mechanisms become less effective and the epigenetic effects of Helicobacter pylori infection and environmental carcinogens more difficult to reverse. AA: ascorbic acid; BMD: bone marrow derived; cdx: caudal type homeobox gene; c-erbB: human epidermal growth factor oncogene; CDH1: E-cadherin gene; GSH: glutathione; HPE: Helicobacter pylori eradication, LOH: loss of heterozygosity; SPEM: spasmolytic polypeptide-expressing metaplasia; TET1: ten eleven translocation methylcytosine dioxygenase 1 [6,19,26].