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. 2020 Sep 1;21(17):6348. doi: 10.3390/ijms21176348

Figure 6.

Figure 6

Structural and MAPK remodeling of cardiomyocytes in the myocardium of patients with dilated cardiomyopathy. (A) Confocal images of a transplanted patient with end-stage dilated cardiomyopathy (DCM). Upper images show an α-actinin-1 (Actinin-1)- and P-Erk-1/2-positive cell isolated from other cardiomyocytes in a fibrotic area of the myocardium. P-ERK1/2 indicates that the MAPK is still intact. Middle images depict α-actinin-1 positive cardiomyocyte expressing BNP. Lower images show cardiomyocytes reexpressing α-actinin-1 as well as Erk3. Controls show neither ERK3 nor actinin-1 expression. V indicates a vessel and serves as positive control for actinin-1. (B) Confocal fluorescence images of a transplanted 12-year-old patient with left ventricular assist device. Note the P-ERK1/2-decreasing gradient from the right ventricle (RV) over the septum (Sep) to the left ventricle (LV). LV control serves an age-matched patient with Tetralogy of Fallot.