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. 2020 Aug 24;21(17):6103. doi: 10.3390/ijms21176103

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Characterization of standard ligands in the β-arrestin2 recruitment assay. A set of agonists (A) and antagonists (B) were tested for their ability to promote or inhibit (the quinpirole-induced) β-arrestin recruitment at the D_2longR and the D₃R. Data of agonists were normalized to the maximal stimulation induced by 1 µM quinpirole (100%) and a solvent control (0%). Antagonist data were normalized to the signal elicited by quinpirole at a concentration corresponding to the EC₈₀ (100%) and a solvent control (0%). Obtained pEC₅₀, E_max and pK_b values are presented in Table 2. Data represent means ± SEM from at least three independent experiments, each performed in triplicate.