Table 1.

T cells and macrophages are key players in both the anti-cancer immune response and tuberculosis. Their roles, the cytokines involved, and potential immunotherapies are briefly summarized here.

Summary Table
T Cells
	Tuberculosis	TME
Role	Activation of M. tuberculosis infected macrophages to stimulate mycobacterial killing Possess an effector role that has potential to be modified through immunotherapy [2]	Elimination of Cancer Cells Immunomodulation of the TME with an effector role that has been modified through immunotherapy [20]
Cytokines	IFNγ, TNF-α, IL-6, IL-12, IL-1β
Immunotherapies	Anti-PD-1/PD-L1	Anti-PD-1/PD-L1, CAR T cells, TIGIT, OX40, 4-1BB, LAG3, TIM-3, Monalizumab, CTLA-4
Macrophages
	Tuberculosis	TME
Role	The main reservoir for M. tuberculosis Work in conjunction with T cells to kill mycobacteria [2]	Immunomodulatory roles through cytokine production Effector role that can be modified through immunotherapy [21,22,23]
Cytokines	iNOS, IFNγ, TNF-α, IL-6, IL-1β, IL-10, IL-4, IL-2
Immunotherapies	CD40 agonists [23] Rifampicin [24]	CD40 agonists [23] β-Glucan [25] STAT3 [22]