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Scheme for polarization strategies. Treg, regulatory T cells. After reperfusion, microglia, astrocytes, neutrophils, regulatory T cells (Treg), PBMCs, M2-like polarized stem cells, A2 astrocytes, and N2 neutrophils may induce a protective, anti-inflammatory state via factors such as cytokines. Thus, mild ischemia and drugs may suppress inflammation and prompt tissue remodeling to salvage a lesion in patients with stroke.
