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. 2020 Sep 1;21(17):6336. doi: 10.3390/ijms21176336

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Recalibrating apoE functions by increasing lipidation. Therapeutic strategies to improve the lipidated state of apoE include the use of: (1) Small molecules that enhance ABCA1 activity, (2) Liver X receptor (LXR) and retinoid X receptor (RXR) agonists to increase the expression of ABCA1, ABCG1 and APOE, (3) regulation of micro-RNAs to increase ABCA1 expression, (4) small molecules as apoE4 structure correctors, (5) anti-apoE4 immunotherapy targeting non-lipidated apoE, and (6) recalibrating apoE function by using AAV-APOE2 biologic therapy.