Table 4.
Genotypes and Alleles frequencies in unexposed and OP-exposed groups.
| Genotype | Cameroon | Pakistan | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Unexposed n (%) | Exposed n (%) | OR (95% CI) | χ2 (p-Value) | Unexposed n (%) | Exposed n (%) | OR (95% CI) | χ2 (p-Value) | ||
| GSTP1 | AA | 70 (56) | 84 (42) | 6.167 (0.045) | 34 (30.36) | 47 (23.5%) | 1.810 (0.404) | ||
| AG | 34 (27.2) | 75 (37.5) | 57 (50.89) | 114 (57) | |||||
| GG | 21 (16.8) | 41 (20.5) | 21 (18.75) | 39 (19.5) | |||||
| DM AG + GG vs. AA | 0.569(0.362–0.893) | 6.047 (0.013) | 0.704 (0.419–1.184) | 1.756 (0.185) | |||||
| RM AG + AA vs. GG | 1.240 (0.692–2.220) | 0.526 (0.468) | 1.050 (0.582–1.893) | 0.026 (0.871) | |||||
| A | 174 (69.6) | 242 (60.5) | 0.666 (0.476–0.932) | 5.641 (0.017) | 125 (55.80) | 208 (52) | 0.858 (0.617–1.192) | 0.834 (0.360) | |
| G | 76 (30.4) | 158 (39.5) | 99 (44.20 | 192 (48) | |||||
| CAT | AA | 68 (54.4) | 67 (33.5) | 14.05 (0.009) | 67 (59.82) | 74 (37) | 15.80 (0.001) | ||
| AT | 48 (38.4 | 115 (57.5) | 30 (26.78) | 93 (46.5) | |||||
| TT | 9 (7.2) | 18 (9) | 15 (13.40) | 33 (16.5) | |||||
| DM AT + TT vs. AA | 0.422 (0.267–0.667) | 13.84 (0.002) | 0.394 (0.245–0.634) | 15.10 (0.001) | |||||
| RM AT + AA vs. TT | 1.275 (0.553–2.934) | 0.327 (0.567) | 1.278 (0.660–2.472) | (0.532) 0.465 | |||||
| A | 184 (73.6) | 249 (62.25) | 0.554 (0.388–0.792) | 8.912 (0.002) | 164 (73.21) | 241 (60.25) | 0.591 (0.418–0.836) | 10.59 (0.001) | |
| T | 66 (26.4) | 151 (37.75) | 60 (26.79) | 159 (39.5) | |||||
| BCHE | GG | 26 (20.8) | 33 (16.5) | 34.97 (0.000) | 56 (50) | 70 (35) | 8.695 (0.01) | ||
| GA | 70 (56) | 56 (28) | 35 (31.25) | 66 (33) | |||||
| AA | 29 (23.2) | 111 (55.5) | 21 (18.75) | 64 (32) | |||||
| DM GA + AA vs. GG | 1.329 (0.750–2.353) | 0.957 (0.327) | 1.857 (1.160–2.974) | 6.710 (0.01) | |||||
| RM GA + GG vs. AA | 0.247 (0.149–0.408) | 31.61 (0.000) | 0.490 (1.979–16.58) | 12.73 (0.001) | |||||
| G | 122 (48.8) | 122 (30.5) | 0.460 (0.332–0.638) | 21.97 0.000 | 147 (65.63) | 206 (51.5) | 0.556 (0.280–0.858) | 6.359 (0.01) | |
| A | 128 (51.2) | 278 (69.5) | 77 (34.37) | 194 (48.4) | |||||
| ACHE | GG | 85 (68) | 110 (55) | 9.843 (0.007) | 70 (62.5) | 78 (39) | 21.14 (0.001) | ||
| GT | 23 (18.4) | 69 (34.5) | 38 (33.93) | 87 (43.5) | |||||
| TT | 17 (13.6) | 21 (10.5) | 4 (3.57) | 35 (17.5) | |||||
| DM GT + TT vs. GG | 0.575 (0.360–0.918) | 5.417 (0.019) | 0.383 (0.238–0.617) | 15.90 (0.001) | |||||
| RM GT + GG vs. TT | 0.745 (0.376–1.475) | 0.715 (0.397) | 5.72 (1.979–16.58) | 12.73 (0.001) | |||||
| G | 193 (77.2) | 289 (72.25) | 0.768 (0.532–1.111) | 1.967 0.160 | 178 (79.46) | 243 (60.75) | 0.400 (0.273–0.585) | 22.91 (0.001) | |
| T | 57 (22.8) | 111 (27.75) | 46 (20.54) | 157 (39.25) | |||||
| SIRT1 | GG | 28 (22.4) | 39 (19.5) | 2.5 (0.286) | 45 (40.18) | 81 (40.5) | 0.23 (0.891) | ||
| GA | 82 (65.6) | 124 (62) | 44 (39.29) | 74 (37) | |||||
| AA | 15 (12) | 37 (18.5) | 23 (20.53) | 45 (22.5) | |||||
| DM GA + AA.Vs GG | 0.839 (0.485–1.45) | 0.395 (0.529) | 1.013 0.632–1.624 | 0.003 (0.957) | |||||
| RM GA + GG vs. AA | 1.665 (0.871–3.179) | 2.41 (0.119) | 1.123 (0.637–1.979) | 0.162 (0.686) | |||||
| G | 138 (55.2) | 202 (50.5) | 0.828 (0.602–1.137) | 1.362 (0.243) | 134 (59.82) | 236 (59) | 0.966 (0.692–1.349) | 0.040 (0.841) | |
| A | 112 (44.8) | 198 (49.5) | 90 (40.18) | 164 (41) | |||||
| GSTM1 | Present (+) | 106 (84.8) | 143 (71.5) | 0.449 (0.252–0.800) | 7.595 (0.005) | 96 (85.71 | 175 (87.5) | 1.167 (0.593–2.29)2 | 0.200 (0.654) |
| Absent (−) | 19 (15.2) | 57 (28.5) | 16 (14.29) | 25 (12.5) | |||||
| GSTT1 | Present (+) | 108 (86.4) | 149 (74.5) | 0.459 (0.251–0.839) | 6.584 0.010 | 94 (83.93) | 172 (86) | 1.176 (0.618–2.239) | 0.245 (0.620) |
| Absent (−) | 17 (13.6) | 51 (25.5) | 18 (16.07) | 28 (14) | |||||