Table 2.

Preclinical and clinical evidences related to NLRP3 inflammasome activation in TBI.

References	Preclinical Evidences ( = Increase)	Clinical Evidences ( = Increase)
Liu et al. 2013		caspase-1
Ma et al. 2016	NLRP3, caspase-1 and IL-1β
Wei et al. 2016	NLRP3, caspase-1 and IL-1β
Chen et al. 2019		NLRP3, IL-1β IL-18, caspase-1
Chiaretti et al. 2005		IL-1β, IL-6