Figure 11.

Therapeutic targets for brain injury for nanoparticle mediated drug delivery. Brain injury leads to a cascade of secondary damage events (denoted in grey boxes). These secondary injuries are potential targets for therapeutics where NP delivery may be useful. Potential intervention strategies are highlighted with red/green/blue font where inhibitors/blocking agents are in red, neuroprotective agents via pathway modulation in green, and targeting ligands in blue. Reproduced from [178], with permission from John Wiley and Sons, 2017.