Table 1.

Assessment of the risk of bias in animal studies using SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE) *.

First Author (Year) [Reference]	Selection Bias			Performance Bias		Detection Bias		Attrition Bias (Drop-Outs)	Other Biases
	Random Group Allocation	Baseline Group Characteristic	Allocation Concealed	Random Housing	Blinding of Examiners	Random Outcome Selection	Blinding of Assessor		Any Randomization	Any Blinding	Size Calculation	Temp Control
Morell (2016) [33]	L	H	H	?	?	H	?	?	Y	N	N	Y
De Petrocellis (2013) [45]	?	H	H	?	H	H	?	?	N	N	N	Y
Roberto (2019) [46]	L	H	?	?	?	?	?	?	Y	N	N	N
Olea-Herrero (2009) [50]	?	L	?	?	?	?	?	?	N	N	N	N
Mukhtar (2007) [51]	?	H	?	?	?	?	?	?	N	N	N	N
Morales (2013) [52]	?	H	?	?	?	H	?	?	N	N	N	N

* H = high risk of bias; L = low risk of bias; ? = unclear; Y = yes reported; N = not reported.