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The natural history of non-alcoholic fatty liver disease (NAFLD) and its etiological risk factor. The prevalence of NAFL was around 20–30%. Around 15–20% of non-alcoholic simple fatty liver (NAFL) patients developed non-alcoholic steatohepatitis (NASH); 10–20% of NASH patients will further process to cirrhosis and Hepatocellular carcinoma (HCC). Several factors including genetic susceptibility, environmental stress, diet, and gut microbiota were considered as etiological risk factors.
