HCC |
hepatocellular carcinoma |
NAFLD |
non-alcoholic fatty liver disease |
NASH |
non-alcoholic steatohepatitis |
HBV |
hepatitis B viruses |
HCV |
hepatitis C viruses |
SCFA |
short chain fatty acid |
ZO-1 |
zonula occludens-1 |
DSS |
dextran sodium sulfate |
IL10 |
interleukin-10 |
IL6 |
interleukin-6 |
PPAR |
peroxisome proliferator-activated receptor |
FMT |
fecal microbial transplantation |
HFDs |
high-fat diets |
NLRP6 |
nucleotide-binding oligomerization domain -like receptor family pyrin domain containing 6 |
ASC |
apoptosis-associated speck-like protein containing a caspase recruitment domain |
TLR4 |
toll-like receptor 4 |
HSCs |
hepatic stellate cells |
LSECs |
liver sinusoidal endothelial cells |
MyD88 |
myeloid differentiation primary response 88 |
TNF-α |
tumor necrosis factor-α |
ROS |
reactive oxygen species |
JNK |
c-Jun N-terminal kinase |
PAMPs |
pathogen-associated molecular patterns |
NEFAs |
non-esterified fatty acids |
S1P |
sphingosine 1-phosphate |
TRAIL |
TNF-related apoptosis-inducing ligand |
DAMP |
damage-associated molecular pattern |
GPR |
G-protein coupled receptor |
HDAC |
histone deacetylase |
CREB |
cyclic adenosine monophosphate (cAMP) response element binding protein |
BCAAs |
branched-chain amino acids |
AAAs |
aromatic amino acids |
ACADSB |
acyl-CoA dehydrogenase short/branched chain |
IA |
indoleacrylic acid |
IAA |
indole-3-acetic acid |
I3A |
indole-3-aldehyde |
IPA |
indole-3-propionic acid |
SREBP1c |
sterol regulatory element-binding protein-1c |
AhR |
aryl-hydrocarbon receptor |
PXR |
pregnane X receptor |
CA |
cholic acid |
CDCA |
chenodeoxycholic acid |
DCA |
deoxycholic acid |
LCA |
lithocholic acid |
FXR |
farnesoid X receptor |
TGR5 |
takeda G-protein-coupled bile acid receptor 5 |
OCA |
obeticholic acid |
FGF |
fibroblast growth factor |
VLDL |
very low-density lipoprotein |
TMA |
trimethylamine |
TMAO |
trimethylamine-N-oxide |
CXCL6 |
chemokine ligand 6 |