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. 2020 Aug 20;21(17):5999. doi: 10.3390/ijms21175999
HCC hepatocellular carcinoma
NAFLD non-alcoholic fatty liver disease
NASH non-alcoholic steatohepatitis
HBV hepatitis B viruses
HCV hepatitis C viruses
SCFA short chain fatty acid
ZO-1 zonula occludens-1
DSS dextran sodium sulfate
IL10 interleukin-10
IL6 interleukin-6
PPAR peroxisome proliferator-activated receptor
FMT fecal microbial transplantation
HFDs high-fat diets
NLRP6 nucleotide-binding oligomerization domain -like receptor family pyrin domain containing 6
ASC apoptosis-associated speck-like protein containing a caspase recruitment domain
TLR4 toll-like receptor 4
HSCs hepatic stellate cells
LSECs liver sinusoidal endothelial cells
MyD88 myeloid differentiation primary response 88
TNF-α tumor necrosis factor-α
ROS reactive oxygen species
JNK c-Jun N-terminal kinase
PAMPs pathogen-associated molecular patterns
NEFAs non-esterified fatty acids
S1P sphingosine 1-phosphate
TRAIL TNF-related apoptosis-inducing ligand
DAMP damage-associated molecular pattern
GPR G-protein coupled receptor
HDAC histone deacetylase
CREB cyclic adenosine monophosphate (cAMP) response element binding protein
BCAAs branched-chain amino acids
AAAs aromatic amino acids
ACADSB acyl-CoA dehydrogenase short/branched chain
IA indoleacrylic acid
IAA indole-3-acetic acid
I3A indole-3-aldehyde
IPA indole-3-propionic acid
SREBP1c sterol regulatory element-binding protein-1c
AhR aryl-hydrocarbon receptor
PXR pregnane X receptor
CA cholic acid
CDCA chenodeoxycholic acid
DCA deoxycholic acid
LCA lithocholic acid
FXR farnesoid X receptor
TGR5 takeda G-protein-coupled bile acid receptor 5
OCA obeticholic acid
FGF fibroblast growth factor
VLDL very low-density lipoprotein
TMA trimethylamine
TMAO trimethylamine-N-oxide
CXCL6 chemokine ligand 6