Table 2.

Specificity and tissue localization of the most important miRNAs involved in neurodegenerative diseases.

miRNAs	Specificity	Localization	References
miR-26b ↑	AD, PD	CNS, Blood	[43]
miR-206 ↑	AD, ALS	CSF	[44]
miR-34a ↑	AD, PD, HD	CNS, Blood	[45]
miR-126 ↑	AD, PD	CNS	[46]
miR-9 ↓	AD	Cortex	[47]
miR-221 ↓	AD	Cortex	[48]
miR-98 ↑	AD	Cortex	[49]
miR-330 ↓	AD, HD	CNS	[50]
miR-19 ↓	AD, PD	CNS	[51]
miR-30 ↓	AD, PD	Blood, CSF	[17]
miR-375 ↓	AD	CSF	[53]
miR-7 ↓	PD	CNS	[52]
miR-124 ↓	PD, AD	CNS	[54]
miR-133b ↓	PD, HD, ALS	CNS, Cortex	[74]
miR-153 ↓	PD	CNS	[55]
miR-443 ↑	PD	CNS	[56]
miR-494 ↑	PD	CSF	[57]
miR-34b/c ↓	PD, AD, HD	CNS, Blood	[58]
miR-205 ↓	PD	CNS	[59]
miR-27a ↓	PD, ALS	CNS	[60]
miR-105 ↓	PD, AD	CSF	[60]
miR-103 ↑	PD, AD	CNS, Blood	[60]
miR 4639 5p ↓	PD	CNS	[61]
miR-21 ↑	PD, AD	Lymphocytes, CSF, Blood	[62]
miR-331-5p ↑	PD	CNS, Blood	[63]
miR-132 ↓	HD, ALS, AD	CNS, CSF, Cortex, Cerebellum	[64]
miR-125b ↓	HD, AD	CNS, Hippocampus	[65]
miR-146a ↓	HD, AD, ALS	CSF, Spinal cord	[66]
miR-196a ↓	HD	Cortex	[67]
miR-9 ↑	HD, AD, ALS	CNS	[68]
miR-124 ↑	HD, AD	CSF, Hippocampus, Cortex	[69]
miR-29a ↑	HD, AD, PD	Cortex, Blood	[69]
miR-129-5p ↑	ALS. PD	Cerebellum, CSF	[70]
miR-27a/b ↓	ALS	Monocytes CD14 + CD16-	[72]
miR-335-5p ↑	ALS	CNS	[72]
miR-151b ↓	ALS, HD, AD	Cortex, CNS	[73]
miR-221-3p ↓	ALS	CNS	[73]
miR-130a-3p ↓	ALS	CNS	[73]

↑ = miRNA upregulated in related disease; ↓ = miRNA downregulated in related disease. AD = Alzheimer’s disease; PD = Parkinson’s disease; HD = Huntington’s disease; ALS = Amyotrophic lateral sclerosis; CNS = central nervous system; CSF = cerebrospinal fluid.