Figure 2.

The P2Y1- and P2Y12-mediated signal transduction pathway and their potential involvement in platelet extracellular vesicles (PEVs) formation: a detailed description can be found in the text. Abbreviations: AC—adenylyl cyclase; ADP—adenosine diphosphate; ATP—adenosine triphosphate; cAMP—cyclic adenosine monophosphate; Ca²⁺—calcium; DAG—diacylglycerol; Gi—GTP-binding protein i; Gq—GTP-binding protein q; IP3—inositol trisphosphate; PIP2—phosphatidylinositol bisphosphate; PI3-K—phosphoinositide 3-kinase; PKC—protein kinase C; PLCβ—phospholipase C β.